By KRZYSZTOF SZCZUBIAŁKA of JAGIELLONIAN UNIVERSITY in KRAKOW
Blood clotting, medically called haemostasis or coagulation, is a very complicated process by which blood turns from a liquid into a solid, called a clot. The process is crucial for maintaining blood circulation in all higher animals; clots form, plugging broken blood vessels and preventing blood loss from ruptured veins or arteries. If blood could not clot, even the slightest cut could be fatal, as has been the case for haemophiliacs, until quite recently. Clot formation is a final effect of a sequence of reactions among about 30 proteins called coagulation factors. A product of one reaction is usually used in another reaction, and the complete set of these reactions is usually called a coagulation cascade. The cascade-like nature of blood coagulation explains why blood may not coagulate properly if even a single coagulation factor is absent, defective, or present in blood in an abnormal concentration. Thus, weak blood clotting may lead to haemorrhages, while excessive coagulation may cause the formation of clots within blood vessels. Both situations may be life-threatening, causing heart infarcts, brain strokes or serious diseases like deep vein thrombosis or pulmonary embolism.